Designated Players
As of May 6, 2013
| NAME | TEAM | STATUS |
| CURRENT | ||
| Alvaro Fernandez | Chicago Fire | Current (On Loan) |
| Sherjill MacDonald | Chicago Fire | Current |
| Federico Puppo | Chicago Fire | Current (On Loan) |
| Oswaldo Minda | Chivas USA | Current |
| Federico Higuaín | Columbus Crew | Current |
| Rafael Texeira de Souza | D.C. United | Current |
| David Ferreira | FC Dallas | Current |
| Fabian Castillo | FC Dallas | Current |
| Oscar Boniek Garcia | Houston Dynamo | Current |
| Robbie Keane | LA Galaxy | Current |
| Landon Donovan | LA Galaxy | Current |
| Marco Di Vaio | Montreal Impact | Current |
| Jerry Bengston | New England Revolution | Current |
| Tim Cahill | New York Red Bulls | Current |
| Thierry Henry | New York Red Bulls | Current |
| Jose Kleberson | Philadelphia Union | Current (on loan) |
| Diego Valeri | Portland Timbers | Current |
| Diego Chará | Portland Timbers | Current |
| Javier Morales | Real Salt Lake | Current |
| Alvaro Saborío | Real Salt Lake | Current |
| Chris Wondolowski | San Jose Earthquakes | Current |
| Obafemi Martins | Seattle Sounders FC | Current |
| Mauro Rosales | Seattle Sounders FC | Current |
| Shalrie Joseph | Seattle Sounders FC | Current |
| Fredy Montero | Seattle Sounders FC | On Loan |
| Claudio Bieler | Sporting Kansas City | Current |
| Danny Koevermans | Toronto FC | Current |
| Matias Laba | Toronto FC | Current |
| Kenny Miller | Vancouver Whitecaps FC | Current |
| FORMER | ||
| Cuauhtémoc Blanco | Chicago Fire | Former |
| Nery Castillo | Chicago Fire | Former |
| Juan Pablo Ángel | Chivas USA | Former |
| Guillermo Barros-Schelloto | Columbus Crew | Former |
| Andres Mendoza | Columbus Crew | Former |
| Luciano Emilio | D.C. United | Former |
| Marcelo Gallardo | D.C. United | Former |
| Branko Boskovic | D.C. United | Former |
| Hamdi Salihi | D.C. United | Former |
| Denilson | FC Dallas | Former |
| Luis Angel Landin | Houston Dynamo | Former |
| David Beckham | Los Angeles Galaxy | Former |
| Milton Caraglio | New England Revolution | Former |
| Claudio Reyna | New York Red Bulls | Former |
| Frank Rost | New York Red Bulls | Former |
| Kris Boyd | Portland Timbers | Former |
| Geovanni | San Jose Earthquakes | Former |
| Blaisé Nkufo | Seattle Sounders FC | Former |
| Freddie Ljundberg | Seattle Sounders FC/Chicago Fire | Former |
| Claudio Lopez | Sporting Kansas City | Former |
| Jeferson | Sporting Kansas City | Former |
| Omar Bravo | Sporting Kansas City | Former |
| Torsten Frings | Toronto FC | Former |
| Mista | Toronto FC | Former |
| Barry Robson | Vancouver Whitecaps FC | Former |
| Eric Hassli | Vancouver Whitecaps FC | Former |
| Mustapha Jarju | Vancouver Whitecaps FC | Former |